Mutations in the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 are frequently found in gliomas. Mutations in an HLA-class II binding CD4 T-cell epitope of IDH1, termed IDH1R132H, are present in 70-80% of WHO grade II and III glioma patients. In collaboration with Berlkeley Lights Inc., scientists at UCSF have recently cloned cDNAs that code for T-cell receptors that react with a peptide derived from isocitrate dehydrogenase 1 mutated at residue 132 (IDH1R132H). Immunizing mice bearing IDH1R132H-transfected syngeneic sarcomas with the IDH1R132H peptide was shown to have an anti-tumor effect. The cDNAs developed can, therefore, be used to develop adoptive T-cell therapies for cancers bearing the IDH1R132H mutation.
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Country | Type | Number | Dated | Case |
United States Of America | Published Application | 20210087252 | 03/25/2021 | 2017-067 |
European Patent Office | Published Application | 3749349 | 12/16/2020 | 2017-067 |
T Cell Receptor, Adoptive Cell Therapy, Glioma, Isocitrate Dehydrogenase, Cancer Immunotherapy